Protein Details: P2X purinoceptor 3
Protein ID
ICDB_Pro_0625
Protein Name
P2X purinoceptor 3
Gene Name
P2RX3
Organism
Homo sapiens (Human)
Length
397 amino acids
AlphaFoldDB
AF-P56373-F1-model_v4.pdb
Function
Receptor for ATP that acts as a ligand-gated cation channel. Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity).
Sequence
Ligand Binding
Binding Site
BINDING 63..65; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000269|PubMed:27626375;ECO:0007744|PDB:5SVK;ECO:0007744|PDB:5SVL;ECO:0007744|PDB:5SVM;ECO:0007744|PDB:5SVP"; BINDING 172; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000269|PubMed:27626375;ECO:0007744|PDB:5SVK;ECO:0007744|PDB:5SVL;ECO:0007744|PDB:5SVM;ECO:0007744|PDB:5SVP"; BINDING 275; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000269|PubMed:27626375;ECO:0007744|PDB:5SVK;ECO:0007744|PDB:5SVL;ECO:0007744|PDB:5SVM;ECO:0007744|PDB:5SVP"; BINDING 279..281; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000269|PubMed:27626375;ECO:0007744|PDB:5SVK;ECO:0007744|PDB:5SVL;ECO:0007744|PDB:5SVM;ECO:0007744|PDB:5SVP"; BINDING 299; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000269|PubMed:27626375;ECO:0007744|PDB:5SVK;ECO:0007744|PDB:5SVL;ECO:0007744|PDB:5SVM;ECO:0007744|PDB:5SVP"
Disease
Dissociative Amnesia and Chronic Rapidly Progressive Glomerulonephritis
Location
DOI ID
10.1124/mol.51.1.109; 10.1038/nature04632; 10.1101/gr.2596504; 10.1038/nature19367
RefSeq
NP_002550.2; XP_011543371.1; XP_011543372.1